The CDC head said the genetic sequencing of viruses from the cluster so far has yielded four main findings:
The isolates are all "virtually identical," implying a single source.
They are susceptible to the antiviral drug Tamiflu (oseltamivir).
"There is no evidence of motif changes in the particular areas of the genes that are responsible for how the virus binds to the respiratory tract of people."
The isolates are very similar to viruses previously collected from poultry in the region.
The above comments from the CDC are similar to comments from Hong Kong. Both groups receive human samples from Indonesia as indicated in the WHO update. However, as with the earlier WHO updates, more information is available from what is not said in the reports. Since only part of human sequence has been made public (HA and NA from the first confirmed case in July of 2005), more sequence interpretations come from short and well parsed comments, such as those above.
The first two confirmed cases in Indonesia were associated with short descriptions which contained subtle differences. The released sequence from the first case in 2005 has a novel cleavage site (RESRRKKR), which is why it was not called “virtually identical” but was said to have ”high homology” with poultry sequences, which have the more common cleavage site (RERRRKKR). The second sequence in 2005 was called “essentially the same” as poultry (as opposed to essentially the same as the first human sequence), indicating it had the RERRRKKR cleavage site. Thus, there were two sequences in human cases in the Jakarta area. Source : RFecombinomicsCDC :